Significance Of The Discovery Of Clodronate Liposome

By Roxanne Cruz


Medical science, being one of the most fascinating field in the industry has found different solutions to different problems over time. Before, yellow fever for example killed thousands of residents in different areas. But because of the discoveries of the assiduous medical scientists, yellow fever vaccine was invented. Clodronate liposome is one of those outstanding discoveries that will play a great role in the field of medicine.

Clodronate disodium or clodronic acid, or known commonly as clodronate is the first generation of bisphosphonate without nitrogen. It is a medicine and is approved to be used for the prevention and treatment of osteoporosis cases to women who are at their post menopausal stage. It is also said to deplete macrophages.

These are white blood cells within tissues. Macrophages are produced by the division of the white blood cells formed in the bone marrow and spleen. These kind of white blood cell is known to be as monocytes which ingest foreign particles after it was formed. Basically, macrophage is the core of the system which fight against infectious viruses and diseases.

In cell biology, liposomes are the tiny bubble which are composed of fatty sacs with liquid inside. These are used in both research and experiment in cell biology. It is filled with drugs that are used to cure cancer and different diseases. It is filled with liquid and phospholipids.

Clodronate liposome is a discovery which functions to suppress the macrophage. It is true that immune system fights bacteria and viruses. Through various steps so called the immune response, the system attacks these infectious invaders that may cause disease. But at the same time, this system could also be a culprit in the human body.

In most circumstances, the immune system helps the body cope up diseases like fever and colds. However, when it is damaged, it will attack all the cells including the healthy ones. With a stroke of misfortune, several grave disorders will take place.

Immune response does protect the body from invasion of the infectious organisms. But damages will also happen in the body when the transplant was rejected leading to the autoimmune condition. Transplant rejection is the side effect of the immune response. When a new organ is placed on the patient, cells will automatically work against forcefully to the organ cells. It will soon result to transplant rejection.

Medical people discovered a certain drug that will treat and cure cases like those. This is made of bisphosphonate the will lessen macrophage. It will be transplanted to the organ cell and as soon as it detected that it is foreign, it will automatically cover the whole transplant up and try to eat them through the so called phagocytosis.

Clodronate liposome also helps to improve anti tumor effects caused by anti tumor drugs during cancer. This may not be able to cure the disease but somehow it will increase plasma absorption. Though this discovery is of great significance in the medical science, before actually resorting in taking it, consult you doctor first.




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